February 25, 2007Cardiovascular Research

Developmental expression of myostatin in cardiomyocytes and its effect on foetal and neonatal rat cardiomyocyte proliferation

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Why the study?

Does recombinant myostatin inhibit proliferation in isolated foetal and neonatal rat cardiomyocytes?

Population

Isolated cardiomyocytes from rat myocardium at different developmental ages

Design

Preclinical

Authors

GMGodfrina McKoyUniversity of London KBKatrina A. BicknellUniversity of Reading KPKantilal M. PatelUniversity of California, San Francisco

Discussion

Member takes

Implication

Does not support clinical translation; leaves open myostatin modulation for human cardiomyocyte regeneration.

Structured PICO

Does recombinant myostatin inhibit proliferation in isolated foetal and neonatal rat cardiomyocytes?

Population

Isolated cardiomyocytes from rat myocardium at different developmental ages (foetal day 18 and postnatal day 10)

Intervention

Recombinant myostatin

Outcome

Cardiomyocyte proliferation and cell viabilitysurrogate

Myostatin acts as an inhibitor of cardiomyocyte proliferation during cardiac development, potentially limiting hyperplastic growth by altering cell cycle progression.

Cite This Study

McKoy et al. (2007) studied this question.

synapsesocial.com/papers/6a90ebadc8472108f273c754 https://doi.org/10.1016/j.cardiores.2007.02.023

View Full Paper

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Developmental expression of myostatin in cardiomyocytes and its effect on foetal and neonatal rat cardiomyocyte proliferation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Developmental expression of myostatin in cardiomyocytes and its effect on foetal and neonatal rat cardiomyocyte proliferation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider