August 26, 2005Cardiovascular Research

Insulin-like growth factor-1 mediates stretch-induced upregulation of myostatin expression in neonatal rat cardiomyocytes

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Why the study?

Does cyclic stretch increase myostatin expression in neonatal rat cardiomyocytes?

Population

Neonatal Wistar rat cardiomyocytes and an in vivo model of aorta-caval shunt in adult rats

Comparison

Cyclic stretch and administration of inhibitors vs Non-stretched myocytes

Design

Preclinical

Follow-up

6 to 18 hours

Authors

KSKou‐Gi ShyuFu Jen Catholic University WKW.H. KoSun Yat-sen University WYWei‐Shiung YangNational Taiwan University

Discussion

Member takes

Implication

Does not support clinical translation; leaves open myostatin's role in human cardiac remodeling.

Structured PICO

Does cyclic stretch increase myostatin expression in neonatal rat cardiomyocytes?

Population

Neonatal Wistar rat cardiomyocytes and an in vivo model of aorta-caval shunt in adult rats

Intervention

Cyclic stretch (vacuum to 20% of maximum elongation at 60 cycles/min) and administration of inhibitors (SB203580, IGF-1 monoclonal antibody, p38 siRNA)

Comparator

Non-stretched myocytes

Outcome

Myostatin protein and mRNA expressionsurrogate

Cyclic mechanical stretch enhances myostatin expression in cultured rat neonatal cardiomyocytes, mediated by IGF-1 through a p38 MAP kinase and MEF2 pathway.

Cite This Study

Shyu et al. (2005) studied this question.

synapsesocial.com/papers/6a9108329d3e7f78367a6784 https://doi.org/10.1016/j.cardiores.2005.06.028

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Insulin-like growth factor-1 mediates stretch-induced upregulation of myostatin expression in neonatal rat cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Insulin-like growth factor-1 mediates stretch-induced upregulation of myostatin expression in neonatal rat cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider