June 16, 2007AJP Heart and Circulatory Physiology

Mechanical stretch enhances the expression of resistin gene in cultured cardiomyocytes via tumor necrosis factor-α

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Population

Cultured neonatal Wistar rat cardiomyocytes grown on a flexible membrane base

Design

Preclinical

Follow-up

2-18 hours

Authors

BWBao-Wei WangFu Jen Catholic University HHHuei-Fong HungMemorial Hospital HCHang ChangLawrence Berkeley National Laboratory

Discussion

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Implication

May link mechanical stretch to cardiomyocyte metabolic changes via resistin; leaves open human relevance and therapeutic targeting.

Structured PICO

Population

Cultured neonatal Wistar rat cardiomyocytes grown on a flexible membrane base

Intervention

Cyclic mechanical stretch by vacuum to 20% of maximum elongation at 60 cycles/min

Outcome

Resistin protein and mRNA expressionsurrogate

Cyclic mechanical stretch induces resistin expression in cardiomyocytes via TNF-alpha, ERK, and NF-kappaB pathways, leading to reduced glucose uptake.

Cite This Study

Wang et al. (2007) studied this question.

synapsesocial.com/papers/6a84f73f412f1be49af1182a https://doi.org/10.1152/ajpheart.00361.2007

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Mechanical stretch enhances the expression of resistin gene in cultured cardiomyocytes via tumor necrosis factor-α

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanical stretch enhances the expression of resistin gene in cultured cardiomyocytes via tumor necrosis factor-α

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider