Why the study?
Does carvedilol reduce myostatin expression and ventricular remodeling in adult Sprague-Dawley rats with volume-overload heart failure?
Population
Adult Sprague-Dawley rats with volume-overload heart failure induced by aorto-caval shunt
Comparison
Carvedilol, N-acetylcysteine, or doxazosin vs Untreated shunt group
Design
Preclinical
Follow-up
4 weeks
Authors
Loading...
Hypothesis-generating for myostatin modulation by carvedilol in experimental HF; leaves open human translation.
Does carvedilol reduce myostatin expression and ventricular remodeling in adult Sprague-Dawley rats with volume-overload heart failure?
In a rat model of volume-overload heart failure, carvedilol reversed the up-regulation of myocardial myostatin expression and associated ventricular remodeling.
Shyu et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: