Population
Rabbit models (in vitro platelet aggregation and in vivo arteriovenous-shunt model)
Comparison
SR 121787 and SR 121566 vs Clopidogrel, aspirin, and other GP IIb/IIIa…
Design
Preclinical
Follow-up
Up to 6 hours post-dose
Authors
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Premature for clinical antiplatelet use; extends preclinical evidence for oral GP IIb/IIIa antagonists beyond clopidogrel and aspirin.
SR 121787 is an orally active GP IIb/IIIa antagonist that demonstrates potent antiplatelet and antithrombotic activity in rabbit models, unlike other tested GP IIb/IIIa antagonists.
Hoffmann et al. (1997) studied this question.
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