Key result
SR 121566A demonstrated acute antithrombotic effects across multiple animal species (ED50 0.007-0.50 mg/kg) with hemorrhagic effects only observed at 2-3 times the antithrombotic ED50.
Population
In vitro human samples and animal models (baboons, dogs, marmosets, guinea pigs, rabbits)
Design
Preclinical
Authors
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Supports progression to human trials; leaves open clinical translation of antithrombotic efficacy and safety.
SR 121566A demonstrates potent antithrombotic efficacy with a favorable hemostatic safety profile across multiple animal species, supporting its potential as an antithrombotic agent in humans.
Bernat et al. (1999) studied this question. SR 121566A was evaluated on Antiplatelet, antithrombotic, and hemorrhagic actions. SR 121566A demonstrated acute antithrombotic effects across multiple animal species (ED50 0.007-0.50 mg/kg) with hemorrhagic effects only observed at 2-3 times the antithrombotic ED50.
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