January 1, 1994Thrombosis and Haemostasis

Antithrombotic Effects and Bleeding Time Prolongation with Synthetic Platelet GPIIb/llla Inhibitors in Animal Models of Platelet-Mediated Thrombosis

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Population

Hamsters with standardized femoral vein endothelial cell injury predisposing to platelet-rich mural…

Design

Preclinical

Authors

DCD CollenVascular / Pulmonary Vascular HLHua Rong LuElectrophysiology JSJean–Marie StassenBoehringer Ingelheim (Germany)

Discussion

Member takes

Implication

Suggests potential for safer GPIIb/IIIa inhibitors; leaves open translation to clinical settings.

Structured PICO

Population

Hamsters with standardized femoral vein endothelial cell injury predisposing to platelet-rich mural thrombosis, and dogs with a carotid arterial eversion graft inserted in the femoral artery

Intervention

Intravenous administration of synthetic platelet GPIIb/IIIa inhibitors G4120 or TP9201

Outcome

In vivo thrombus formation, ex vivo ADP-induced platelet aggregation, and template bleeding timesurrogate

The synthetic GPIIb/IIIa inhibitor TP9201 prevents platelet-mediated thrombosis without prolonging bleeding time in animal models, suggesting a potentially safer profile than G4120.

Cite This Study

Collen et al. (1994) studied this question.

synapsesocial.com/papers/6a90eecdefab70d99b73d35f https://doi.org/10.1055/s-0038-1642390

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Antithrombotic Effects and Bleeding Time Prolongation with Synthetic Platelet GPIIb/llla Inhibitors in Animal Models of Platelet-Mediated Thrombosis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Antithrombotic Effects and Bleeding Time Prolongation with Synthetic Platelet GPIIb/llla Inhibitors in Animal Models of Platelet-Mediated Thrombosis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider