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September 1, 1992BloodOpen Access

Antithrombotic properties of L-cysteine, N-(mercaptoacetyl)-D-Tyr-Arg- Gly-Asp-sulfoxide (G4120) in a hamster platelet-rich femoral vein thrombosis model

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Authors

YIYuki ImuraTanabe Research LaboratoriesJSJM StassenUniversitair Ziekenhuis LeuvenSBS BuntingBlackpool Teaching Hospitals NHS Foundation Trust

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Implication

Randomized trial evaluates G4120's effect on thrombus formation in a hamster model, suggesting potential clinical use.

Key Points

  • This research investigates the antithrombotic effects of the synthetic peptide G4120 in a hamster thrombosis model.
  • Thrombosis induced using endothelial cell damage in hamsters.
  • G4120 administered via bolus intravenous injection.
  • Thrombus formation and platelet aggregation measured in response to G4120 and RGDF.
  • G4120 inhibited platelet aggregation with an IC50 of 0.05 microgram/mL in human plasma.
  • In vivo thrombus formation inhibition by G4120 showed an ID50 of 11 micrograms/kg.
  • RGDF resulted in 43% inhibition of thrombus formation at a dose of 30 mg/kg.

Cite This Study

Imura et al. (1992) studied this question.

synapsesocial.com/papers/6a711980c92390ac2d07e502https://doi.org/10.1182/blood.v80.5.1247.1247
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