Why the study?
Does intracoronary Ac-RGDS-NH2 prevent platelet-dependent thrombus formation in a dog model compared to Ac-RGES-NH2?
Population
Dog model of acute platelet-dependent thrombus formation in the coronary artery and in vitro platelet…
Comparison
Ac-RGDS-NH2 infused intracoronary at… vs Ac-RGES-NH2 infused intracoronary at similar…
Design
Preclinical
Authors
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Ac-RGDS-NH2 shows antithrombotic potential intracoronarily in dogs; leaves open translation to human coronary interventions.
Does intracoronary Ac-RGDS-NH2 prevent platelet-dependent thrombus formation in a dog model compared to Ac-RGES-NH2?
Ac-RGDS-NH2 is an effective and specific antiplatelet agent that inhibits thrombus formation when administered intracoronary in a dog model.
Shebuski et al. (1989) studied this question.
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