Why the study?
Interpreting serial cardiac biomarkers in aortic valve stenosis is challenging due to difficulty distinguishing real changes from random fluctuation, requiring robust biological variation estimates.
Establishing the biological variation of cardiac biomarkers in stable moderate AVS enables clinicians to better distinguish true clinical changes from random fluctuations during serial monitoring.
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Biological variation estimates may refine serial BNP/NT-proBNP interpretation in AVS; leaves open prospective validation before clinical adoption.
Peeters et al. (2019) studied this question.
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