What question did this study set out to answer?

To evaluate the mechanisms of high-dose intravenous vitamin C on neutrophil extracellular trap formation and endothelial glycocalyx degradation in patients with sepsis-induced acute respiratory distress syndrome.

October 21, 2022NutrientsOpen Access

Biological Effects of Intravenous Vitamin C on Neutrophil Extracellular Traps and the Endothelial Glycocalyx in Patients with Sepsis-Induced ARDS

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Authors

XQXian QiaoSentara Norfolk General Hospital MKMarkos KashiourisVirginia Commonwealth University MLM. L'HeureuxVirginia Commonwealth University

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Implication

Randomized trial analysis shows intravenous vitamin C attenuates cell-free DNA and syndecan-1 in sepsis-induced ARDS, indicating reduced vascular barrier damage and inflammation.

Key Points

To evaluate the mechanisms of high-dose intravenous vitamin C on neutrophil extracellular trap formation and endothelial glycocalyx degradation in patients with sepsis-induced acute respiratory distress syndrome.
Conducted a post hoc biomarker analysis of 167 patients (84 receiving high-dose intravenous vitamin C and 83 receiving placebo) enrolled in the randomized placebo-controlled CITRIS-ALI trial.
Measured plasma cell-free DNA (a marker of neutrophil extracellular trap formation) and syndecan-1 (a marker of endothelial glycocalyx breakdown) at baseline and 48 hours.
At 48 hours, patients treated with vitamin C exhibited a 1.02 ng/µL greater reduction in cell-free DNA than placebo recipients (baseline: 2.18 ± 4.20 ng/µL vs. 2.65 ± 3.87 ng/µL; p = 0.05).
At 48 hours, syndecan-1 increased by 0.75 ng/mL (95% CI, 0.21 to 1.29) in the vitamin C group compared to an increase of 1.53 ng/mL (95% CI, 0.96 to 2.11) in the placebo group (p = 0.05).

Cite This Study

Qiao et al. (2022) studied this question.

synapsesocial.com/papers/6a90ef4cc39ca0eda1830071 https://doi.org/10.3390/nu14204415

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Implication

Randomized trial analysis shows intravenous vitamin C attenuates cell-free DNA and syndecan-1 in sepsis-induced ARDS, indicating reduced vascular barrier damage and inflammation.

Biological Effects of Intravenous Vitamin C on Neutrophil Extracellular Traps and the Endothelial Glycocalyx in Patients with Sepsis-Induced ARDS

Discussion

Member takes

Implication

Key Points

Cite This Study

Biological Effects of Intravenous Vitamin C on Neutrophil Extracellular Traps and the Endothelial Glycocalyx in Patients with Sepsis-Induced ARDS

Discussion

Member takes

Implication

Key Points

Cite This Study

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