December 1, 1988European Journal of Immunology

Orientation of epitopes influences the immunogenicity of synthetic peptide dimmers

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Population

Inbred mice (CBA/ca, C57BL/6, BALB/c, B10.D2)

Comparison

Synthetic peptide dimers based on epitope… vs Monomers or alternative orientations of the…

Design

Preclinical

Authors

JCJosephine H. CoxUniversity of Nigeria JIJuraj IványiKing's College London DYDouglas B. YoungUniversity of Cape Town

Discussion

Member takes

Implication

Hypothesis-generating for orientation-optimized peptide dimers in vaccines; human studies needed before clinical consideration.

Structured PICO

Population

Inbred mice (CBA/ca, C57BL/6, BALB/c, B10.D2)

Intervention

Synthetic peptide dimers based on epitope sequences derived from the mycobacterial 65-kDa antigen (65-85, 422-436) and the foot and mouth disease virus (FMDV) VP1 protein (141-160)

Comparator

Monomers or alternative orientations of the hybrid dimers

Outcome

Antibody response and T cell stimulationsurrogate

Combining heterologous peptides with the N-terminal of the mycobacterial 65-85 sequence may be a generally applicable strategy for potentiating peptide vaccines.

Cite This Study

Cox et al. (1988) studied this question.

synapsesocial.com/papers/6a90f6643ef1f7fbbf3e7ca0 https://doi.org/10.1002/eji.1830181222

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Orientation of epitopes influences the immunogenicity of synthetic peptide dimmers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Orientation of epitopes influences the immunogenicity of synthetic peptide dimmers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider