Why the study?
Does treatment with adrenalectomy or spironolactone improve endothelial progenitor cell numbers and arterial stiffness in patients with primary aldosteronism?
Population
168 patients at a tertiary medical center.
Comparison
Unilateral adrenalectomy or spironolactone vs Essential hypertension patients and…
Design
Cohort
Follow-up
6 months
Authors
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Endothelial recovery after targeted therapy may support treatment benefits in primary aldosteronism; leaves open prospective validation of EPCs for curability prediction.
Does treatment with adrenalectomy or spironolactone improve endothelial progenitor cell numbers and arterial stiffness in patients with primary aldosteronism?
Circulating endothelial progenitor cell numbers are reduced in primary aldosteronism, correlate with arterial stiffness, recover after targeted treatment, and predict hypertension curability following adrenalectomy.
Wu et al. (2011) studied this question.
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