Why the study?
Does increased delivery of free fatty acids provoke dilution of labeled ketone body tracer comparable to that observed in insulin-deficient diabetics?
Population
10 subjects (5 normal controls and 5 insulin-dependent diabetic [IDDM] patients)
Comparison
Infusion of labeled [3,4-13C2]-acetoacetate; in… vs Normal subjects vs IDDM subjects; basal state vs…
Design
Other
Authors
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Pseudoketogenesis undetectable across forearm even with elevated FFAs; leaves open its contribution to tracer dilution in diabetes.
Does increased delivery of free fatty acids provoke dilution of labeled ketone body tracer comparable to that observed in insulin-deficient diabetics?
The study demonstrates that pseudoketogenesis (label exchange between FFA and KB intermediates) could not be detected across the human forearm, even under conditions of increased plasma FFA.
Avogaro et al. (1992) studied this question.
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