Why the study?
Does insulin infusion alter the relationship between blood flow and the uptake of oxygen and metabolic substrates in forearm muscle and subcutaneous fat tissue in healthy and diabetic subjects?
Does insulin infusion alter the relationship between blood flow and the uptake of oxygen and metabolic substrates in forearm muscle and subcutaneous fat tissue in healthy and diabetic subjects?
This physiological study demonstrates that tissue blood flow correlates with oxygen uptake but not with the uptake of individual metabolic substrates, highlighting a dissociation between flow-mediated oxygen delivery and substrate utilization.
Challenges assumption that blood flow predicts substrate uptake with insulin; leaves open mechanisms of perfusion-metabolism uncoupling in diabetes.
Blood flow and arteriovenous differences in oxygen, glucose, lactate, pyruvate, free fatty acids, glycerol, acetoacetate, and β‐hydroxybutyrate were measured in forearm muscle tissue before, during and after insulin infusion, in healthy and diabetic subjects. The same metabolic data were collected for forearm subcutaneous fat tissue. Significant correlations were obtained between the flow and the oxygen uptake in the two tissues both before and after insulin. On the other hand there were no correlations between the flow and the uptake of any single substrate or the total net uptake of the substrates. Concerning the arterial levels of the substrates there was a significant correlation between that of free fatty acids in the diabetics and the muscle blood flow.
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Häggendal et al. (1968) studied this question.
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