Why the study?
Anxiety is associated with increased risk of incident CHD and poor cardiac prognosis, but the underlying pathophysiological mechanisms and biomarkers remain poorly defined.
Do specific biomarkers explain the increased risk of coronary heart disease in patients with anxiety disorders compared to controls?
Comparison
Anxious patients vs controls
Design
Narrative literature review
Authors
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Mechanisms linking anxiety/depression to CHD lack robust evidence; leaves open targeted original studies to define pathophysiology.
Do specific biomarkers explain the increased risk of coronary heart disease in patients with anxiety disorders compared to controls?
Myocardial perfusion and coronary artery calcium are plausible biomarkers linking anxiety to increased CHD risk, though data remains very limited and further studies are needed.
Judith Brouillette (2019) studied this question.
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