Why the study?
Does timolol maleate alter hemodynamics during its initial hypotensive action in patients with essential hypertension?
Does timolol maleate alter hemodynamics during its initial hypotensive action in patients with essential hypertension?
The initial hypotensive action of beta-blockers is preceded by a decrease in cardiac output and an increase in arteriovenous oxygen difference, suggesting early tissue underperfusion plays a role.
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Suggests transient underperfusion with initial timolol in hypertension; hypothesis-generating for beta-blocker mechanisms and requires randomized confirmation.
Colfer et al. (1984) studied this question.
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