Why the study?
Do platelet concentrates derived from pooled buffy coats improve in vitro bleeding time and corrected count increment compared to apheresis-derived platelets in patients with chemotherapy-induced thrombocytopenia?
Population
36 patients with chemotherapy-induced thrombocytopenia receiving 98 platelet transfusions
Comparison
Platelet concentrates derived from pooled buffy… vs Platelet concentrates collected by apheresis…
Design
Cohort
Follow-up
24 hours
Authors
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Fresh platelets may improve recovery in thrombocytopenia; leaves open whether buffy-coat or apheresis sources differ after storage.
Do platelet concentrates derived from pooled buffy coats improve in vitro bleeding time and corrected count increment compared to apheresis-derived platelets in patients with chemotherapy-induced thrombocytopenia?
Fresh platelet concentrates provide better functional recovery than stored ones, and buffy coat-derived platelets perform similarly or slightly better than apheresis-derived platelets.
Eriksson et al. (1996) studied this question.
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