What question did this study set out to answer?

To compare the in vitro functional quality and storage stability of pooled platelet concentrates from whole blood against single-donor apheresis platelet concentrates over a 7-day storage duration.

January 1, 2020Transfusion Medicine and HemotherapyOpen Access

Evaluation of the in vitro Function of Platelet Concentrates from Pooled Buffy Coats or Apheresis

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To compare the in vitro functional quality and storage stability of pooled platelet concentrates from whole blood against single-donor apheresis platelet concentrates over a 7-day storage duration.
Evaluated 20 pooled platelet concentrates (PPCs) and 20 apheresis platelet concentrates (APCs) prepared in plasma on days 2, 4, and 7 of storage.
Assessed metabolic variables, degranulation, aggregation to ADP and collagen, P-selectin expression, annexin V binding, ultrastructural morphology via transmission electron microscopy, and shear stress adhesion in a microfluidic device.
Metabolic stability, chemokine release, soluble P-selectin, soluble CD40L shedding, and shear stress adhesion remained equivalent between PPCs and APCs across the 7-day storage timeframe.
Resting discoid morphology predominated on days 2 and 4, accompanied by low baseline P-selectin expression and preserved P-selectin activation response through day 4 in both concentrate types.
Aggregation responses to ADP and collagen were heterogeneous across concentrates, with marked losses in collagen-induced aggregation occurring in individual units by day 4.

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Implication

Comparative laboratory study demonstrates equivalent in vitro function between pooled and apheresis platelet concentrates, highlighting substantial unit-to-unit variability.

Cite This Study

Fiedler et al. (2020) studied this question.

synapsesocial.com/papers/6a8453b93dbf2f1b7f68c1ab https://doi.org/10.1159/000504917

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Implication

Comparative laboratory study demonstrates equivalent in vitro function between pooled and apheresis platelet concentrates, highlighting substantial unit-to-unit variability.

Evaluation of the in vitro Function of Platelet Concentrates from Pooled Buffy Coats or Apheresis

Key Points

Discussion

Implication

Cite This Study

Evaluation of the in vitro Function of Platelet Concentrates from Pooled Buffy Coats or Apheresis

Key Points

Discussion

Implication

Cite This Study

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