Microslide tubes provide a quick, simple, and inexpensive in vitro screen for compounds to prevent Chagas's disease transmission via blood transfusion.
May enable rapid, low-cost screening for Chagas transfusion safety; leaves open clinical translation pending in vivo validation.
This paper describes how Microslide tubes can be used as the basis for a quick, simple, inexpensive screen to test for compounds which might prevent the transmission of Chagas's disease as a result of blood transfusion. The test uses Trypanosoma cruzi-infected mouse blood and requires only very small amounts of compound. The screen identifies compounds known to be active against blood trypomastigotes in vitro at 4 degrees C, and is apparently free of false negative and positive results.
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Cover et al. (1982) studied this question.
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