Why the study?
Although myocarditis and pericarditis incidence increases during acute COVID-19, whether they are part of long COVID-19 syndrome after recovery remains unknown.
Does prior COVID-19 infection increase the incidence of myocarditis and pericarditis in unvaccinated adults?
Does prior COVID-19 infection increase the incidence of myocarditis and pericarditis in unvaccinated adults?
Supports investigation of post-COVID cardiac autoimmunity; leaves open need for prospective confirmation before practice change.
Background and Aim: Viral infections have also been associated with the presence of autoimmune diseases such as systemic lupus disease, rheumatoid arthritis, and diabetes mellitus. SARS-CoV-2 gains entry into human cells by binding its spike protein to the membrane protein angiotensinconverting enzyme 2 (ACE2). It has recently been reported that the incidence of myocarditis and pericarditis is increased in COVID-19 patients during the acute illness. However; whether or not myocarditis and pericarditis after the recovery period are a part of the long COVID-19 syndrome is yet unknown. Hence, we studied the incidence of myocarditis and pericarditis in COVID-19 patients after recovering from the acute infection. Material and Methods: We retrieved records of all adult patients (age ≥ 18 years) who had a documented positive COVID-19 PCR test (n = 500) for the period of 1 year. A control group was created from a cohort of adult patients with at least one negative COVID-19 From this pool of patients, the control cohort was created by 3:1 matching of age (±2 years) and gender. Total 1000 patients in control group were selected.
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Patel et al. (2022) studied this question.
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