Why the study?
Do purine and pyrimidine 2',3'-dideoxynucleosides inhibit duck hepadnavirus replication in vitro and in vivo?
Population
Duck hepadnavirus (in vitro) and animal model infected with hepadnavirus (in vivo)
Comparison
Purine and pyrimidine 2',3'-dideoxynucleosides vs Comparison between different…
Design
Preclinical
Authors
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May guide nucleoside analog selection for hepadnaviruses; leaves open human HBV translation from duck models.
Do purine and pyrimidine 2',3'-dideoxynucleosides inhibit duck hepadnavirus replication in vitro and in vivo?
2,6-diaminopurine 2',3'-dideoxyriboside demonstrates potent in vivo efficacy in clearing duck hepadnavirus DNA.
Lee et al. (1989) studied this question.
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