September 1, 1972Antimicrobial Agents and ChemotherapyOpen Access

3-Deazauridine: Inhibition of Ribonucleic Acid Virus-Induced Cytopathogenic Effects In Vitro

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Why the study?

Does 3-deazauridine inhibit virus-induced cytopathogenic effects in mammalian cell cultures infected with RNA viruses?

Population

Mammalian cell cultures infected with ribonucleic acid-containing animal viruses

Design

Preclinical

Follow-up

12 to 24 hours after infection

Authors

WSWilliam M. ShannonNew South Wales Department of Health GAGussie ArnettSouthern Research Institute FSFrank M. SchabelSouthern Research Institute

Discussion

Member takes

Implication

In vitro activity against RNA viruses is hypothesis-generating; leaves open any clinical role for 3-deazauridine.

Structured PICO

Does 3-deazauridine inhibit virus-induced cytopathogenic effects in mammalian cell cultures infected with RNA viruses?

Population

Mammalian cell cultures infected with ribonucleic acid-containing animal viruses (rhinovirus types 1A and 13, coxsackievirus type A21, PR-8 influenza virus, poliovirus type 2, or echovirus type 12)

Intervention

3-Deazauridine

Outcome

Inhibition of virus-induced cytopathogenic effects and extracellular yield of progeny virussurrogate

3-Deazauridine demonstrates in vitro antiviral activity against specific RNA viruses, including rhinovirus and influenza, by reducing cytopathogenic effects and viral yield.

Cite This Study

Shannon et al. (1972) studied this question.

synapsesocial.com/papers/6a8a779e1e528df4f2ec73be https://doi.org/10.1128/aac.2.3.159

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September 1, 1972Antimicrobial Agents and ChemotherapyOpen Access

3-Deazauridine: Inhibition of Ribonucleic Acid Virus-Induced Cytopathogenic Effects In Vitro

View Full Paper

Ask AI

Bookmark

Why the study?

Does 3-deazauridine inhibit virus-induced cytopathogenic effects in mammalian cell cultures infected with RNA viruses?

Population

Mammalian cell cultures infected with ribonucleic acid-containing animal viruses

Design

Preclinical

Follow-up

12 to 24 hours after infection

Authors

WSWilliam M. ShannonNew South Wales Department of Health GAGussie ArnettSouthern Research Institute FSFrank M. SchabelSouthern Research Institute

Discussion

Member takes

Implication

In vitro activity against RNA viruses is hypothesis-generating; leaves open any clinical role for 3-deazauridine.

Structured PICO

Does 3-deazauridine inhibit virus-induced cytopathogenic effects in mammalian cell cultures infected with RNA viruses?

Population

Mammalian cell cultures infected with ribonucleic acid-containing animal viruses (rhinovirus types 1A and 13, coxsackievirus type A21, PR-8 influenza virus, poliovirus type 2, or echovirus type 12)

Intervention

3-Deazauridine

Outcome

Inhibition of virus-induced cytopathogenic effects and extracellular yield of progeny virussurrogate

3-Deazauridine demonstrates in vitro antiviral activity against specific RNA viruses, including rhinovirus and influenza, by reducing cytopathogenic effects and viral yield.

Cite This Study

Shannon et al. (1972) studied this question.

synapsesocial.com/papers/6a8a779e1e528df4f2ec73be https://doi.org/10.1128/aac.2.3.159

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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