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May 1, 2002Clinical and Experimental Pharmacology and Physiology

Weight Reduction Decreases Soluble Cellular Adhesion Molecules In Obese Women

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Why the study?

Does a lifestyle-modification programme reduce soluble cellular adhesion molecules in non-diabetic normotensive obese women?

Population

32 non-diabetic normotensive obese women

Comparison

3-month lifestyle-modification programme… vs No lifestyle-modification programme

Design

Cohort

Follow-up

3 months

Authors

AOAkiko OhshimaAsahi University MIMisako InoueOtsuma Women's University NONaoko OhtoThai Health Promotion Foundation

Discussion

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Implication

Lifestyle intervention was associated with reduced endothelial activation markers in obese women; hypothesis-generating and should not yet change practice.

Structured PICO

Does a lifestyle-modification programme reduce soluble cellular adhesion molecules in non-diabetic normotensive obese women?

P

Population

32 non-diabetic normotensive obese women

I

Intervention

3-month lifestyle-modification programme consisting of lectures on diet, exercise sessions, and behavioural modification by weight charting

C

Comparator

No lifestyle-modification programme (control group)

O

Outcome

Change in soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin) at 3 monthssurrogate

Weight reduction through lifestyle modification decreases soluble adhesion molecules, suggesting a downregulation of endothelial activation and potential reduction in atherosclerotic risk in obese women.

Cite This Study

Ohshima et al. (2002) studied this question.

synapsesocial.com/papers/6a91074568768914f6830ecc https://doi.org/10.1046/j.1440-1681.2002.03672.x

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