Why the study?
Does isometric handgrip exercise cause an exaggerated blood pressure response in patients with essential hypertension, and how do propranolol and prazosin affect this response?
Population
58 subjects, including 46 patients with essential hypertension and 12 normotensive controls, under constant…
Comparison
Isometric handgrip exercise, with acute… vs Normotensive controls and unsuppressed baseline…
Design
Cross-sectional
Authors
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Exaggerated BP response to isometric exercise in hypertension may involve alpha-1 receptors; hypothesis-generating for targeted blockade.
Does isometric handgrip exercise cause an exaggerated blood pressure response in patients with essential hypertension, and how do propranolol and prazosin affect this response?
Patients with essential hypertension exhibit an exaggerated blood pressure response to isometric exercise, which appears to be mediated by alpha-1 adrenoceptors as it is partially suppressed by prazosin but not propranolol.
Hamada et al. (1987) studied this question.
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