January 1, 1991Journal of Experimental Biology

Lactate Utilization By AnIn SituPerfused Trout Heart: Effects Of Workload And Blockers Of Lactate Transport

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Population

In situ perfused trout heart preparation

Comparison

Perfusion with modified Cortland saline… vs Different lactate concentrations and absence of…

Design

Preclinical

Authors

CMC. Louise MilliganBoston Children's Hospital AFAnthony P. FarrellUniversity of British Columbia

Discussion

Member takes

Implication

Supports carrier-mediated lactate uptake in trout heart; hypothesis-generating for cardiac substrate transport in other species.

Structured PICO

Population

In situ perfused trout heart preparation

Intervention

Perfusion with modified Cortland saline containing 0.5 mmol l-1 iodoacetic acid and varying amounts of lactate (1 or 10 mmol l-1), with or without lactate transport blockers (α-CIN, isobutyl carbonyl lactyl anhydride, or 4-acetamido-4'-isothiocyano-stilbene-2,2'-disulphonic acid)

Comparator

Different lactate concentrations (1 vs 10 mmol l-1) and absence of transport blockers

Outcome

Lactate utilization and cardiac performancesurrogate

Lactate uptake by the in situ perfused trout heart appears to be carrier-mediated, as putative transport blockers abolish lactate oxidation without impairing cardiac performance.

Cite This Study

Milligan et al. (1991) studied this question.

synapsesocial.com/papers/6a910c30c27f1af0e592dbd6 https://doi.org/10.1242/jeb.155.1.357

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Lactate Utilization By AnIn SituPerfused Trout Heart: Effects Of Workload And Blockers Of Lactate Transport

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Lactate Utilization By AnIn SituPerfused Trout Heart: Effects Of Workload And Blockers Of Lactate Transport

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider