Why the study?
Does siRNA-2A reduce viral replication and improve survival in CVB3-infected type I interferon receptor-knockout mice?
Does siRNA-2A reduce viral replication and improve survival in CVB3-infected type I interferon receptor-knockout mice?
RNA interference targeting the 2A protease of coxsackievirus B3 attenuates viral replication and improves survival in a susceptible mouse model, suggesting a potential therapeutic approach for enteroviral diseases.
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Hypothesis-generating for siRNA-2A in enteroviral myocarditis; should not yet change clinical practice.
Merl et al. (2005) studied this question.
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