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May 1, 1988HepatologyOpen Access

Ventricular function in cirrhosis and portasystemic shunt: A two-dimensional echocardiographic study

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Why the study?

Does chronic portasystemic shunt cause clinically significant cardiac strain or alter ventricular function in patients with cirrhosis?

Population

50 patients, comprising 30 patients with cirrhosis and 20 patients chronically treated with portasystemic…

Comparison

Chronic portasystemic shunt vs Patients with cirrhosis without portasystemic…

Design

Cross-sectional

Follow-up

16 to 156 months (shunt duration)

Authors

HKHelmut KellerHeidelberg UniversityVBVera BezjakHeidelberg UniversityBSB StegaruHeidelberg University

Discussion

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Overview

Portasystemic shunts associate with increased LV volumes but preserved systolic function in cirrhosis; leaves open long-term cardiac effects and need for prospective studies.

Structured PICO

Does chronic portasystemic shunt cause clinically significant cardiac strain or alter ventricular function in patients with cirrhosis?

P
Population
50 patients, comprising 30 patients with cirrhosis and 20 patients chronically treated with portasystemic shunt for prevention of hemorrhage from esophageal variceal bleeding.
I
Intervention
Chronic portasystemic shunt (duration 16 to 156 months)
C
Comparator
Patients with cirrhosis without portasystemic shunt
O
Outcome
Ventricular function and hemodynamic patterns measured by two-dimensional echocardiography (including left ventricular end-diastolic volume index, left ventricular end-systolic index, cardiac output, heart rate, left ventricular stroke volume index, and systolic ventricular performance)surrogate

Chronic portasystemic shunts in cirrhotic patients cause hemodynamic changes including increased left ventricular volumes, but do not result in clinically significant cardiac strain or impaired systolic function.

Cite This Study

Keller et al. (1988) studied this question.

synapsesocial.com/papers/6a910eb8d2f2d69b3a745e98https://doi.org/10.1002/hep.1840080337

Topics

Echocardiography
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Also Consider

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  1. 1Measurement of left ventricular ejection fraction by mechanical cross-sectional echocardiography.1979 · 155 citations
  2. 2Skeletal muscle blood flow and neurovascular reactivity in liver disease1973 · 61 citations
  3. 3Studies of the Cardiovascular System in the Hypotension of Liver Failure1962 · 94 citations