Population
In vitro transcription/translation system translating murine tissue inhibitor of metalloproteinases…
Comparison
5'-truncated TIMP transcript lacking the segment… vs TIMP transcript containing the segment including…
Design
Preclinical
Authors
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May modulate TIMP in cardiac remodeling; leaves open relevance to human disease.
The 5' leader sequence containing an upstream open reading frame modulates the translation efficiency of murine TIMP mRNA, suggesting a mechanism for amplifying expression in response to serum.
Waterhouse et al. (1990) studied this question.
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