Why the study?
Does stimulation of the right versus left hypothalamus elicit different cardioaccelerator and cardioaugmentor responses in dogs?
Does stimulation of the right versus left hypothalamus elicit different cardioaccelerator and cardioaugmentor responses in dogs?
This preclinical study demonstrates lateralized control of cardiac function in the hypothalamus of dogs, suggesting ipsilateral descent of sympathetic pathways.
Lateralized hypothalamic cardiac responses in dogs warrant no clinical extrapolation; leaves open sympathetic pathway mapping for translational research.
Comparison of cardioaccelerator and cardioaugmentor responses elicited from the two halves of the hypothalamus of 21 open-chested, vagotomized dogs under chloralose anesthesia showed that stimulation of the right side generally resulted in marked acceleration accompanied by moderate augmentation, whereas stimulation on the left caused pronounced augmentation associated with only moderate acceleration. These differences in degree were statistically significant. This finding suggests that the hypothalamic sympathetic pathways for the cardiac controls, like those of other sympathetic functions, descend predominantly on the ipsilateral sides of the spinal cord.
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Fang et al. (1962) studied this question.
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