Key result
Vagosympathetic stimulation confirms direct bilateral ventricular augmentor fiber innervation in dogs.
Why the study?
The existence and distribution of ventricular augmentor fibers in the cervical vago-sympathetic trunk were not previously established.
Establishes direct ventricular sympathetic innervation in dogs; leaves open translation to human autonomic therapies.
The existence of ventricular augmentor fibers in the cervical vago-sympathetic trunk of the dog has been established by electrical stimulation after atropine. These fibers are distributed directly to both right and left ventricles, although preliminary evidence indicates disproportionate supply to the right ventricle. Augmentation in atrial systole during vagal stimulation after atropine also indicates significant innervation of atrial musculature, but these influences may often be subordinate to alterations in mean atrial pressure. Cardioaccel-erator responses may or may not accompany the augmentor changes in intraventricular pressure, and are usually more characteristic of right vagal stimulation.
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Randall et al. (1967) studied this question. Electrical stimulation after atropine was evaluated on Existence and distribution of ventricular augmentor fibers. Electrical stimulation of the cervical vagosympathetic trunk after atropine in dogs established the existence of ventricular augmentor fibers distributed directly to both ventricles.
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