Population
Neuronal models for studying nitric oxide synthase (NOS) function and excitotoxic injury
Comparison
Down-modulation or up-modulation of neuronal… vs Baseline/normal neuronal MA levels
Design
Preclinical
Authors
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Methylarginine modulation of excitotoxicity warrants study in mammalian models; leaves open human therapeutic relevance.
Endogenous methylarginines act as critical intrinsic inhibitors of neuronal NOS, and their pharmacological modulation could offer a novel approach to prevent excitotoxic neuronal injury.
Cardounel et al. (2002) studied this question.
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