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The persistence of a circadian rhythm is reported in the mitotic activity of a mammary carcinoma of a C3H/Mza female mouse after 35 transplant generations carried out over a 3-year period. The possible causes of the different results found in the literature on mitotic rhythms in malignant tumors are analyzed. The antitumor effect of Endoxan administered at different times during a 24-hour period is also reported. This drug is more effective if administered when the mitotic activity of the tumor is high (4 am, 8 am, noon, and 4 pm) than when the mitotic activity is low (8 pm and midnight). The practical importance of this fact is emphasized.
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Badrán et al. (1965) studied this question.
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