June 25, 2001The Journal of Cell BiologyOpen Access

The Dictyostelium Carmil Protein Links Capping Protein and the Arp2/3 Complex to Type I Myosins through Their Sh3 Domains

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Population

Dictyostelium cells

Comparison

p116 (CARMIL) deletion/knockout vs Wild-type cells

Design

Preclinical

Authors

GJGoeh JungNational Institutes of Health KRKirsten RemmertNational Institutes of Health XWXufeng WuNational Institutes of Health

Discussion

Member takes

Implication

CARMIL emerges as a key actin regulator in Dictyostelium; leaves open its conservation and relevance in mammalian cells.

Structured PICO

Population

Dictyostelium cells

Intervention

p116 (CARMIL) deletion/knockout

Comparator

Wild-type cells

Outcome

Formation of macropinocytic structures, rate of fluid phase pinocytosis, efficiency of chemotactic aggregation, and cellular F-actin content

Identifies CARMIL as a key linker protein between actin nucleation/termination complexes and type I myosins, essential for actin assembly and cellular processes in Dictyostelium.

Cite This Study

Jung et al. (2001) studied this question.

synapsesocial.com/papers/6a9115b9c27f1af0e592df41 https://doi.org/10.1083/jcb.153.7.1479

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The Dictyostelium Carmil Protein Links Capping Protein and the Arp2/3 Complex to Type I Myosins through Their Sh3 Domains

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Dictyostelium Carmil Protein Links Capping Protein and the Arp2/3 Complex to Type I Myosins through Their Sh3 Domains

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider