This is the third reported case of primary angiosarcoma of the vagina and the first confirmed by light microscopy, immunohistochemistry, and electron microscopy.
Multimodal confirmation of rare primary vaginal angiosarcoma; extends diagnostic literature but leaves management open.
A 73-year-old woman, whose medical history reported radical hysterectomy and radiotherapy for squamous cell carcinoma of the cervix uteri 20 years earlier, was found to have an angiosarcoma of the vagina. The histological diagnosis was confirmed by immunohistochemical staining of tumor cells for factor VIII-related antigen and ultrastructurally defined vasoformative structures. Primary angiosarcoma of the vagina is quite rare and reported in only two published cases. The present case is a third in general, and the first report confirmed by light microscopy, immunohistochemical, and electronmicroscopy studies.
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Tohya et al. (1991) studied this question.
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