Key result
A 43-year-old woman with heavy vaginal bleeding was diagnosed with a rare primary cervical angiosarcoma forming a 5 cm mass with metastatic deposits in the ovaries, fallopian tube, and lymph nodes.
Why the study?
Primary angiosarcoma of the cervix is extremely rare, with only one prior case report.
Case Report (n=1)
This report documents an extremely rare case of primary cervical angiosarcoma, highlighting its histopathological features and differential diagnosis.
Reports second primary cervical angiosarcoma; extends sparse histopathology literature but leaves management undetermined.
Angiosarcomas of the female genital tract are rare and primary angiosarcoma of the cervix is extremely rare with only one prior case report. We report a case of a primary cervical angiosarcoma in a 43-yr-old woman who presented with heavy vaginal bleeding. Cervical biopsy and subsequent radical hysterectomy showed a malignant vascular tumor which was composed of spindled and epithelioid cells and formed abortive vascular channels. Immunohistochemically, the tumor cells were diffusely positive for CD31, CD34, ERG, and cyclin D1 and focally positive for D2-40. A reverse transcription polymerase chain reaction test for YWHAE-NUTM2 genetic fusion was negative excluding a YWHAE-translocated high-grade endometrial stromal sarcoma. The tumor formed a 5 cm mass within the cervix with microscopic involvement of the endometrium, superficial myometrium, and vagina. Metastatic microscopic tumor deposits were present in both ovaries, left fallopian tube, one paracervical lymph node, and one pelvic lymph node. In reporting this unusual case we discuss the differential diagnosis.
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Shah et al. (2018) conducted a case report in Primary cervical angiosarcoma (n=1). Cervical biopsy and radical hysterectomy was evaluated. A 43-year-old woman with heavy vaginal bleeding was diagnosed with a rare primary cervical angiosarcoma forming a 5 cm mass with metastatic deposits in the ovaries, fallopian tube, and lymph nodes.
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