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Do sympathomimetic amines increase cyclic AMP concentrations and adenyl cyclase activity in rabbit heart tissue?
Do sympathomimetic amines increase cyclic AMP concentrations and adenyl cyclase activity in rabbit heart tissue?
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Dopamine and phenylephrine do not increase cyclic AMP concentrations in rabbit heart tissue, suggesting cyclic AMP is not essential for their inotropic effects.
Sympathomimetic amines which increase the contractility of the isolated heart were tested for effects on cyclic AMP concentrations in rabbit heart slices and on adenyl cyclase activity in rabbit heart homogenate.2. Noradrenaline, as expected, stimulated adenyl cyclase activity and increased cyclic AMP concentrations, but dopamine and phenylephrine were ineffective.3. This result does not support the concept that cyclic AMP plays an essential role in the inotropic effect of sympathomimetic amines.
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B. G. Benfey (1971) studied this question.
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