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Sympathomimetic amines can increase cardiac contractility without increasing adenyl cyclase activity.
Both phenylephrine and noradrenaline increased the force of contraction of isolated preparations of rabbit and chicken heart. Noradrenaline increased the rate of formation of cyclic 3′,5′-AMP in homogenate of rabbit or chicken heart, but phenylephrine did not. These results demonstrate that sympathomimetic amines can increase cardiac contractility without increasing the activity of adenyl cyclase.
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Benfey et al. (1971) studied this question.
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