Why the study?
Does the apelin/APJ/Akt/eNOS pathway contribute to the alleviative effect of losartan on renal fibrosis in a mouse UUO model?
Does the apelin/APJ/Akt/eNOS pathway contribute to the alleviative effect of losartan on renal fibrosis in a mouse UUO model?
The apelin/APJ/Akt/eNOS pathway contributes to the protective effects of losartan against renal fibrosis in a mouse model of unilateral ureteral obstruction.
Supports apelin/APJ role in losartan antifibrosis in mice; hypothesis-generating and should not yet change clinical practice.
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Nishida et al. (2012) studied this question.
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