What question did this study set out to answer?

To assess the clinical manifestations, laboratory features, and outcomes of hospitalized patients with confirmed influenza A (H3N2 and H1N1) infections during the 2022–2023 seasonal outbreak in Iran.

August 18, 2024Iranian Journal of Medical MicrobiologyOpen Access

Clinical Characteristics and Outcomes of Influenza A (H3N2/H1N1) Infection in Hospitalized Patients: A Report From Iran 2022-2023 Cold Season Outbreak

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Authors

MSMohammadreza SalehiImam Khomeini Hospital ASArman SoleimanyImam Khomeini Hospital ASAbbas ShakooriImam Khomeini Hospital

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Implication

Observational study reports higher hypoxemia with H3N2 and an 11.55% mortality rate in hospitalized influenza patients, highlighting the urgent need for seasonal vaccination in high-risk groups.

Key Points

To assess the clinical manifestations, laboratory features, and outcomes of hospitalized patients with confirmed influenza A (H3N2 and H1N1) infections during the 2022–2023 seasonal outbreak in Iran.
Observational study analyzing 165 hospitalized patients with RT-PCR-confirmed influenza A at a tertiary hospital complex in Tehran, Iran, between October 2022 and March 2023.
Identified viral subtypes (H3N2 vs. H1N1) via the National Influenza Center and gathered demographic, comorbidity, radiological, and clinical outcome data.
Of 165 hospitalized patients, 148 (89.70%) had H3N2 and 17 (10.30%) had H1N1, presenting most commonly with dyspnea (60.6%), fever (58.8%), and ground glass opacity on imaging (69.1%).
Median oxygen saturation was significantly lower in the H3N2 group at 91% (IQR 81.0–96.0) compared to 95% (IQR 90.0–97.5) in the H1N1 group (P=0.029).
Overall mortality was 11.55% (19/165) and associated with cancer and liver disease, while only one patient had received an influenza vaccination in the preceding year.

Cite This Study

Salehi et al. (2024) studied this question.

synapsesocial.com/papers/6a911ee2e55c7a42f2710e09 https://doi.org/10.30699/ijmm.18.3.181

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Implication

Observational study reports higher hypoxemia with H3N2 and an 11.55% mortality rate in hospitalized influenza patients, highlighting the urgent need for seasonal vaccination in high-risk groups.

Clinical Characteristics and Outcomes of Influenza A (H3N2/H1N1) Infection in Hospitalized Patients: A Report From Iran 2022-2023 Cold Season Outbreak

Discussion

Member takes

Implication

Key Points

Cite This Study

Clinical Characteristics and Outcomes of Influenza A (H3N2/H1N1) Infection in Hospitalized Patients: A Report From Iran 2022-2023 Cold Season Outbreak

Discussion

Member takes

Implication

Key Points

Cite This Study

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