Answers are grounded in this paper and cite their sources.
Addition of lithium acetylides prepared from 1-pentyne, phenylacetylene, and trimethylsilylacetylene to diverse N-tert-butanesulfinyl ketimines affords a range of alpha,alpha-dibranched propargyl sulfinamides in generally good yields (up to 87%) and with high diastereoselectivities (up to >99:1). Acidic cleavage of the tert-butanesulfinyl group provides the free alpha,alpha-dibranched propargylamines.
No takes yet. Share an insight, caveat, or question.
Patterson et al. (2006) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: