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May 1, 1993The International Journal of Artificial Organs

Catheter-Implanted Prosthetic Heart Valves

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Why the study?

Does a catheter-implanted expandable artificial heart valve demonstrate mechanical stability and adequate valve function in porcine models?

Population

36 isolated descending thoracic aorta specimens from 80 kg pigs (in vitro) and six 80 kg pigs (in vivo)

Design

Preclinical

Authors

LKLars KnudsenMedizinische Hochschule HannoverHAHenrik Rasmus AndersenTechnical University of DenmarkJHJ. Michael HasenkamInterventional / Structural Cardiology

Discussion

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Implication

Demonstrates preclinical feasibility in porcine models; leaves open human translation pending clinical trials.

Structured PICO

Does a catheter-implanted expandable artificial heart valve demonstrate mechanical stability and adequate valve function in porcine models?

P
Population
36 isolated descending thoracic aorta specimens from 80 kg pigs (in vitro) and six 80 kg pigs (in vivo)
I
Intervention
Expandable artificial heart valve (porcine aortic valve mounted on an expandable stent) implanted via transluminal catheter technique
O
Outcome
Mechanical stability and valve function (transvalvular pressure differences, leakage flows, stenosis, regurgitation)surrogate

This early preclinical study demonstrates the feasibility, mechanical stability, and hemodynamic function of a novel catheter-implanted expandable artificial heart valve in a porcine model.

Cite This Study

Knudsen et al. (1993) studied this question.

synapsesocial.com/papers/6a912498efab70d99b73e9f8https://doi.org/10.1177/039139889301600505
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transluminal implantation of artificial heart valves. Description of a new expandable aortic valve and initial results with implantation by catheter technique in closed chest pigs1992 · 492 citations
  2. 2A model for acute haemodynamic studies in the ascending aorta in pigs1988 · 28 citations
  3. 3Combined Aortic and Mitral Insufficiency–Hemodynamic Effects of the Hufnagel Valve1956 · 8 citations
  4. 4Early and late results of intracoronary arterial stenting after coronary angioplasty in dogs.1987 · 162 citations
  5. 5Intravascular Stents to Prevent Occlusion and Re-Stenosis after Transluminal Angioplasty1987 · 1,902 citations