Key result
A newly developed transluminal valved stent demonstrated good hemodynamic function in vitro and in vivo in pigs, though positioning and anchoring remained difficult with some stents tilting or migrating.
Early preclinical development of a transluminal heart valve prosthesis demonstrated feasible hemodynamic function but highlighted challenges in positioning and anchoring.
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Animal data support hemodynamic feasibility of transluminal valved stents; leaves open anchoring and positioning challenges before clinical translation.
Kuklinski et al. (2004) studied Aortic valve replacement. Transluminal implantation of a foldable, self-expandable valved stent was evaluated on Hemodynamic function, valve movements, positioning, and anchoring. A newly developed transluminal valved stent demonstrated good hemodynamic function in vitro and in vivo in pigs, though positioning and anchoring remained difficult with some stents tilting or migrating.