What question did this study set out to answer?

To determine whether ferric citrate influences the chemical induction of hepatic δ-aminolevulinic acid synthetase and evaluate the specificity and mechanism of this effect.

May 1, 1970Journal of Biological ChemistryOpen Access

δ-Aminolevulinic Acid Synthetase

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Authors

JSJeffrey A. SteinUniversity of Chicago DTDonald P. TschudyNational Institutes of Health PCPatricia Corcoran

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Implication

Experimental study demonstrates oral ferric citrate synergistically augments hepatic aminolevulinic acid synthetase induction, indicating iron accelerates enzyme synthesis rather than stabilizing it.

Key Points

To determine whether ferric citrate influences the chemical induction of hepatic δ-aminolevulinic acid synthetase and evaluate the specificity and mechanism of this effect.
Administered oral ferric citrate alongside two chemical compounds known to induce hepatic δ-aminolevulinic acid synthetase.
Assessed comparative specificity against inorganic iron salts, non-iron metal citrate complexes, and the control enzyme tyrosine transaminase.
Oral ferric citrate produced a marked synergistic enhancement of hepatic δ-aminolevulinic acid synthetase induction, whereas inorganic iron salts produced no augmentation.
The synergistic effect was selective for iron citrate over other metal citrates and specific to δ-aminolevulinic acid synthetase without affecting tyrosine transaminase.
Hepatic data indicate that iron enhances the rate of de novo enzyme synthesis during induction rather than stabilizing or activating existing enzyme molecules.

Cite This Study

Stein et al. (1970) studied this question.

synapsesocial.com/papers/6a9126b7263aa8e25c73daa3 https://doi.org/10.1016/s0021-9258(18)63141-2

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Implication

Experimental study demonstrates oral ferric citrate synergistically augments hepatic aminolevulinic acid synthetase induction, indicating iron accelerates enzyme synthesis rather than stabilizing it.

δ-Aminolevulinic Acid Synthetase

Discussion

Member takes

Implication

Key Points

Cite This Study

δ-Aminolevulinic Acid Synthetase

Discussion

Member takes

Implication

Key Points

Cite This Study

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