NAMICA Encapsulation Technology in an Animal Model: MICROscale vs. NANOscale Hyaluronic Acid Particles in Skin Remodeling (Part 2)

Hyaluronic acid (HA), an integral non-sulfated glycosaminoglycan, plays a pivotal role in numerous biological functions within the extracellular matrix, crucially influencing tissue hydration and cellular activities. These findings position it as a key substance in both aesthetic interventions and regenerative medicine. This study evaluated the skin remodeling efficacy of poly(L-lactide-co-ε-caprolactone) (P(LA/CL)) threads embedded with HA particles at both the microscale (P(LA/CL)-HA-micro) and nanoscale (P(LA/CL)-HA-nano) utilizing NAMICA encapsulation technology. This investigation was conducted over a six-month period in an animal model. These threads were engineered to administer HA gradually, thereby potentially augmenting the therapeutic impacts on the skin, enhancing the bioavailability of HA, and prolonging the benefits. Methodologically, the research conformed to the ARRIVE guidelines, incorporating specific inclusion and exclusion criteria for the animal model. The threads were surgically implanted, and a series of histological indicators were evaluated at scheduled intervals to determine their influence on the structural properties of the skin. The findings indicated that both P(LA/CL)-HA-micro and P(LA/CL)-HA-nano threads demonstrated potential in skin remodeling. Notably, the P(LA/CL)-HA-nano threads may have provided some advantages in enhancing certain structural aspects of the skin. The integration of micro- and nano-HA formulations through NAMICA technology might address individual limitations and synergistically promote biorevitalization in skin remodeling. Nevertheless, the intricate interactions between the biomaterials and hosted tissue underscored in this analysis suggest that additional investigations, especially using human models, are essential to fully discern the clinical implications and refine therapeutic approaches for skin remodeling via these new technologies.