Why the study?
Is the Glu/Asp polymorphism of the NOS3 gene associated with an increased risk of ischemic stroke?
Population
558 individuals comprising 265 ischemic stroke cases and 293 controls
Comparison
Presence of Glu/Asp polymorphism in codon 298 of… vs Absence of the polymorphism
Design
Case-control
Authors
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No association seen in case-control data; leaves open whether NOS3 Glu/Asp variant influences ischemic stroke risk.
Is the Glu/Asp polymorphism of the NOS3 gene associated with an increased risk of ischemic stroke?
The Glu/Asp polymorphism in the NOS3 gene does not appear to be a genetic risk factor for ischemic stroke.
MacLeod et al. (1999) studied this question.
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