Rubella Vaccinees in a Public School System

Two hundred eighty-three Cendehill strain vaccinees and 268 HPV-77-DK-12 (DK) strain vaccinees in the Princeton School District of Cincinnati were followed up for 4½ years to determine persistence of vaccine-acquired serum antibody. The geometric mean titers (GMT) declined slightly in both groups. Seventeen (8.2%) of the Cendehill vaccinees and nine (4.3%) DK vaccinees experienced a substantial decline in serum antibody levels, while nine (4.3%) of the Cendehill vaccinees and four (6.1%) of the other vaccinees experienced a substantial increase. Clinical rubella was diagnosed in the school system but none of the vaccinees developed clinical evidence of reinfection. The general persistence of vaccine-induced antibody over a 4½-year period was encouraging.