Why the study?
Does the Wistar RA27/3 rubella virus vaccine induce seroconversion in susceptible children and booster responses in previously immune children?
Population
408 children (286 susceptible and 122 with pre-existing rubella antibodies)
Design
Cohort
Authors
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Supports RA27/3 rubella vaccine immunogenicity in children; leaves open need for RCTs to confirm clinical protection.
Does the Wistar RA27/3 rubella virus vaccine induce seroconversion in susceptible children and booster responses in previously immune children?
The RA27/3 rubella vaccine is highly immunogenic in susceptible children and can boost immunity in those with low pre-existing antibody levels.
Henry H. Balfour (1976) studied this question.
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