Why the study?
Cardiovascular medical devices are mostly tested with human blood, prompting investigation into differences between porcine and human platelet behavior upon contact with thrombogenic material.
Population
Porcine and human platelets
Comparison
Porcine platelets vs human platelets exposed to glass in a modified chandler loop-system
Design
In vitro comparative study
Follow-up
4-8 min
Authors
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May refine hemocompatibility testing for porcine cardiovascular models; leaves open human translation.
Minipig and human platelets differ in number and volume but not in activation when exposed to glass, which is relevant for testing hemocompatibility of cardiovascular devices.
Greif et al. (2021) studied this question.
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