Key result
Human platelet adhesion to biomaterials like Cuprophan or Avcothane is negligible compared to dog or rabbit platelets under arterial shear rates, highlighting significant species differences.
Why the study?
Does platelet adhesion to biomaterials differ between mammalian species under controlled blood flow?
Population
Heparinized whole blood from various mammalian species (human, calf, baboon, macaque, hog, sheep, dog, rabbit)
Comparison
Exposure to biomaterials under controlled flow… vs Comparison between species and between…
Design
Preclinical
Follow-up
Up to 180 minutes
Authors
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Animal models may overestimate human platelet adhesion to biomaterials; leaves open the translational validity of non-human testing for device development.
Does platelet adhesion to biomaterials differ between mammalian species under controlled blood flow?
Significant species-dependent differences exist in platelet adhesion to biomaterials, which must be accounted for in thromboresistance testing.
Grabowski et al. (1977) studied this question. Biomaterials (Cuprophan, Avcothane, Gore-Tex, fluorinated ethylcellulose) was evaluated on Platelet adhesion to foreign surfaces. Human platelet adhesion to biomaterials like Cuprophan or Avcothane is negligible compared to dog or rabbit platelets under arterial shear rates, highlighting significant species differences.
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